List of players with highest score in IPL 2016, AB de Villiers from RCB made 129 runs against Guj Lions followed by his teammate V Kohli with 113 runs against Kings XI.
| Player | Runs | Balls | 4s | 6s | Team | Opposition |
| AB de Villiers | 129* | 52 | 10 | 12 | RCB | v Guj Lions |
| V Kohli | 113 | 50 | 12 | 8 | RCB | v Kings XI |
| V Kohli | 109 | 55 | 5 | 8 | RCB | v Guj Lions |
| V Kohli | 108* | 58 | 8 | 7 | RCB | v Supergiants |
| Q de Kock | 108 | 51 | 15 | 3 | Daredevils | v RCB |
| SPD Smith | 101 | 54 | 8 | 5 | Supergiants | v Guj Lions |
| V Kohli | 100* | 63 | 11 | 1 | RCB | v Guj Lions |
| HM Amla | 96 | 56 | 14 | 2 | Kings XI | v Sunrisers |
| DA Warner | 93* | 58 | 11 | 3 | Sunrisers | v Guj Lions |
| DA Warner | 92 | 50 | 9 | 5 | Sunrisers | v RCB |
| G Gambhir | 90* | 60 | 13 | 1 | KKR | v Sunrisers |
| DA Warner | 90* | 59 | 7 | 4 | Sunrisers | v Mum Indians |
| M Vijay | 89 | 57 | 12 | 1 | Kings XI | v RCB |
| KH Pandya | 86 | 37 | 7 | 6 | Mum Indians | v Daredevils |
| RG Sharma | 85* | 60 | 8 | 3 | Mum Indians | v Supergiants |
| RG Sharma | 84* | 54 | 10 | 2 | Mum Indians | v KKR |
| KK Nair | 83* | 59 | 8 | 3 | Daredevils | v Sunrisers |
| AB de Villiers | 83 | 46 | 6 | 4 | RCB | v Supergiants |
| CH Morris | 82* | 32 | 4 | 8 | Daredevils | v Guj Lions |
| S Dhawan | 82* | 57 | 10 | 1 | Sunrisers | v Mum Indians |
| AB de Villiers | 82 | 42 | 7 | 6 | RCB | v Sunrisers |
| PA Patel | 81 | 58 | 10 | 2 | Mum Indians | v Kings XI |
| V Kohli | 80 | 63 | 7 | 2 | RCB | v Supergiants |
| AB de Villiers | 79* | 47 | 5 | 5 | RCB | v Guj Lions |
| V Kohli | 79 | 48 | 7 | 3 | RCB | v Daredevils |
| CH Gayle | 76 | 38 | 4 | 8 | RCB | v Sunrisers |
| V Kohli | 75* | 51 | 5 | 3 | RCB | v KKR |
| V Kohli | 75 | 51 | 7 | 3 | RCB | v Sunrisers |
| SK Raina | 75 | 51 | 9 | 0 | Guj Lions | v Sunrisers |